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  • CAS 107868-30-4 Exemestane/Aromasin Anti Estrogen Steroids Powder An antineoplastic

CAS 107868-30-4 Exemestane/Aromasin Anti Estrogen Steroids Powder An antineoplastic

  • Name:Exemestane
  • CAS No:107868-30-4
  • Purity:99%
  • MF:C20H24O2
  • Appearance:White Crystalline Powder
  • Grade:Pharmaceutical Grade
  • Whatsapp:+86 13545819969
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Port: Shenzhen/Shanghai/HK

Production Capacity: 500kg/Month

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Exemestane11.jpgExemestane (2).jpg


Product Details:

 

Synonyms: 6-methylenandrosta-1,4-diene-3,17-dione;6-METHYLENEANDROSTA-1,4-DIENE-3,17-DIONE;10,13-dimethyl-6-methylidene-7,8,9,10,11,12,13,14,15,16-decahydrocyclopenta[a]phenanthrene-;EXEMESTANE;FCE-24304;AROMASIN;Exemestan;Exemestance

CAS: 107868-30-4

MF: C20H24O2

MW: 296.4

Product Categories: Active Pharmaceutical Ingredients;chiral;Antineoplastic (Hormonal);Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Pfizer compounds;Steroid and Hormone;API;Anti-cancer&immunity;Inhibitors

Mol File: 107868-30-4.mol

Chemical Properties : white to light yellow crystal powder

 

 

Description:


Aromasin (Exemestane acetate) is one of those weird compounds that nobody really knows what to do with. It's a third generation Aromatase Inhibitor (AI) just like Arimidex (Anastrozole) and Femera (Letrozole).
the third generation aromatase inhibitors, used in the treatment of metastatic breast cancer and used as aid in the treatment of early breast cancer.
1. Aromasin is one of the most powerful estrogen suppressing compounds.
2. Aromasin is one of the best compounds to lower the aromatizing effect of steroids.
3. Aromasin is available for body builders taking anabolic steroids.
4. Aromasin is also known as Exemestane.
5. It acts by blocking the enzyme aromatase, subsequently blocking the production of estrogen.
6. Aromasin is also a kind of .antineoplastic (hormonal) raw materials.

 

Aromasin is used to fight breast cancer and raise testosterone in the body.
Exemestane blocks the process of aromatisation. So it lowers the amount of oestrogen in the body. In early breast cancer, taking exemestane can help to stop breast cancer coming back. In advanced breast cancer the cancer cells may grow more slowly or stop growing completely.
Exemestane is an aromatase inhibitor. This means it blocks the enzyme aromatase (found in the body's muscle, skin, breast and fat), which is used to convert androgens (hormones produced by the adrenal glands) into estrogen. In the absence of estrogen, tumors dependent on this hormone for growth will shrink

 

 

 

Applications:


Aromasin is used to fight breast cancer and raise testosterone in the body.
Exemestane acetate blocks the process of aromatisation. So it lowers the amount of oestrogen in the body. In early breast cancer, taking exemestane acetate can help to stop breast cancer coming back. In advanced breast cancer the cancer cells may grow more slowly or stop growing completely.

Most aromatase inhibitors are not steroids in any shape or form but here we must make an exception. Understand, most who buy Aromasin do so because its use with other steroids can often be very important regarding side-effects but Aromasin itself actually carries some androgenic qualities as well. Even so, while possessing an androgenic nature it is its estrogen reducing we are largely concerned with.

the third generation aromatase inhibitors, used in the treatment of metastatic breast cancer and used as aid in the treatment of early breast cancer.
Many breast cancers are stimulated to grow by the female sex hormones oestrogen and progesterone. These breast cancers are called hormone sensitive or hormone receptor positive and can be treated with drugs that block the effects of these hormones.

In women who have had their menopause, oestrogen is mainly produced by changing androgens (sex hormones produced by the adrenal glands) into oestrogens. This process is called aromatisation and happens mainly in the fatty tissues, muscle and the skin. It needs a particular enzyme called aromatase.
Aromasin blocks the process of aromatisation. So it lowers the amount of oestrogen in the body. In early breast cancer, taking Aromasin can help to stop breast cancer coming back. In advanced breast cancer the cancer cells may grow more slowly or stop growing completely.

 

 

Certificate of Analysis:

 

TEST ITEMSSPECIFICATIONRESULTS
DescriptionWhite Crystalline PowderWhite Powder
IdentificationPositivePositive
Assay(by HPLC)98.0~102.0%98.64%
Absorbance(E1cm)465~495482.5
Melting Point191~195°C193.5~195.0°C
Loss On Drying0.5%max0.19%
Specific Rotation+288°~ +298°+290.2°
Residue On Ignition0.1%max0.03%
Related SubstancesTotal:1.5%max<1.3%

Single:0.5%max<0.4%
Residue Solvents0.2%max0.10%
Heavy Metals20PPm max<10PPm

 

Indications and Usage:


Exemestane is an irreversible steroid aromatase inhibitor. Its structure is similar to that of aromatase’s natural substrate, androstenedione, and acts as a pseudosubstrate. Postmenopausal women’s estrogen is mainly converted from androgen (produced by the adrenal cortex) by aromatase in the surrounding tissue. This drug irreversibly binds with the active site on aromatase to deactivate it, thus dramatically lower estrogen levels in the blood circulation of postmenopausal women. By inhibiting aromatase to lower estrogen levels, it can be used to treat hormone-dependent breast cancer in postmenopausal women.
Exemestane is suitable for treating advanced breast cancer in naturally or artificially postmenopausal women that has not responded well to tamoxifen treatment. It is also suitable for treating estrogen and progesterone receptor positive postmenopausal advanced breast cancer, and it can also be used to treat metastasized breast cancer and as adjuvant therapy for early breast cancer.


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1. Rich experience: we specialize in this field for many years, our steroids have been exported almost over the world. Such as USA, Canada, UK, Brazil, Germany, Russia, Australia, Greece, Poland, Bulgaria, Rumania, Netherlands, Sweden, Ukraine, Latvia, Lithuania, Ireland, Austria, Iran, Turkey, Mexico, Thailand, India, Malaysia, Singapore, other Middle East countries, European countries, American countries and more Areas.
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4. Experiential order and cooperation: Besides raw powders, we offer hormone solution and Recipes. We can teach you or discuss how to make hormone solution on the site. Any discussion and question is welcome! 

 


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